of hepar in on l iposomes : possible mechanism of lysis of red blood cel ls by heparin

Heparin causes lysis of the mult i lamellar Iiposomes of all three charges, positive, neutral, and negative 7 and thus releases the entrapped [3H]glucose or chromate. The lyt ic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with the phospholipid bilayers, which suggests that the reported lyric effect of heparin on the red blood cells may be mediated through the membrane phospholipid components of these cells.